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Harrison dahiliye pdf11/5/2022 Anjiyotensin II, renin-anjiyotensin-aldosteron (RAS) sisteminin primer vazoaktif hormonudur ve AT1 reseptörleri yoluyla hipertansiyon patofizyolojisinde anlamlı bir rol oynamaktadır. Anjiyotensin II’nin kaynağı veya sentez yolundan bağımsız olarak AT1’in aracılık yaptığı bütün anjiyotensin II etkilerini bloke ettiği düşünülmektedir. Olmesartan, kuvvetli, oral yoldan etkili, seçici bir anjiyotensin II reseptör tip 1 (AT1) antagonistidir. Keywords: Olmesartan Pioglitazone Carrageenan Inflammation Rat However more de-tailed studies are required to clarify this effect’s mechanism and determine whether this combination will be beneficial in other inflammatory diseases. Discussion: The reason why combined administration of two drugs has potent anti-inflammatory effects may be the simultaneous occur-rence of PPAR-γ receptor activation and AT1 receptor inhibition resulting in a more potent inhibition of inflammatory mediators. Result: Results were showed that olmesartan and piogli-tazone could not exert significant anti-inflammatory effect in single applica-tions while they exerted similar efficacy to standard anti-inflammatory drug indomethacine. 1 hour after drug administration carrageenan was injected to hind-paws of rats and the increase of paw volume was measured five times at one-hour intervals. Material and Method: 5 rat groups received olmesartan (10 mg/kg), pioglitazone (30 mg/kg), olmesartan (10 mg/kg) +pioglitazone (30 mg/kg), indomethacine (25 mg/kg) or distilled water (control group) respec-tively. Results were compared with that of indomethacine as standard anti-inflam-matory agent. Aim: This study investigated effects single and combined administrations of olmesartan, an angiotensin II receptor type I (AT1) antagonist, and pio-glitazone, a peroxisome proliferator-activated receptor-γ (PPAR-γ) ligand on acute phase of inflammation in carrageenan induced inflammation model.
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